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More serious, fetal it may cause heart attack.
Common Causes:
Two major group
- lgE mediated
- Non-lgE mediated
lgE mediated
- True anaphylaxis
- Requires initial sensitizing exposure, the coating of mast cells and basophils by lgE and the explosive release of chemical mediators upon re-exposure.
- Similar to true anaphylaxis but do not require lgE immune reaction.
- Usually caused by the direct stimulation of mast cells and basophils.
- This reaction can happen, and often does, on initial as well as subsequent exposures since no sensitization required.
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